Hadronic unquenching effects in the quark propagator

We investigate hadronic unquenching effects in light quarks and mesons. Within the non-perturbative continuum framework of Schwinger-Dyson and Bethe-Salpeter equations we quantify the strength of the back reaction of the pion onto the quark-gluon interaction. To this end we add a Yang-Mills part of the interaction such that unquenched lattice results for various current quark masses are reproduced. We find considerable effects in the quark mass function at low momenta as well as for the chiral condensate. The quark wave function is less affected. The Gell--Mann-Oakes-Renner relation is valid to good accuracy up to pion masses of 400-500 MeV. As a byproduct of our investigation we verify the Coleman theorem, that chiral symmetry cannot be broken spontaneously when QCD is reduced to 1+1 dimensions.Comment: 27 pages, 15 figures, minor corrections and clarifications; version to appear in PR

Programmable RNA editing with endogenous ADAR enzymes – a feasible option for the treatment of inherited retinal disease?

RNA editing holds great promise for the therapeutic correction of pathogenic, single nucleotide variants (SNV) in the human transcriptome since it does not risk creating permanent off-targets edits in the genome and has the potential for innovative delivery options. Adenine deaminases acting on RNA (ADAR) enzymes catalyse the most widespread form of posttranscriptional RNA editing in humans and their ability to hydrolytically deaminate adenosine to inosine in double stranded RNA (dsRNA) has been harnessed to change pathogenic single nucleotide variants (SNVs) in the human genome on a transcriptional level. Until now, the most promising target editing rates have been achieved by exogenous delivery of the catalytically active ADAR deaminase domain (ADARDD) fused to an RNA binding protein. While it has been shown that endogenous ADARs can be recruited to a defined target site with the sole help of an ADAR-recruiting guide RNA, thus freeing up packaging space, decreasing the chance of an immune response against a foreign protein, and decreasing transcriptome-wide off-target effects, this approach has been limited by a low editing efficiency. Through the recent development of novel circular ADAR-recruiting guide RNAs as well as the optimisation of ADAR-recruiting antisense oligonucleotides, RNA editing with endogenous ADAR is now showing promising target editing efficiency in vitro and in vivo. A target editing efficiency comparable to RNA editing with exogenous ADAR was shown both in wild-type and disease mouse models as well as in wild-type non-human primates (NHP) immediately following and up to 6 weeks after application. With these encouraging results, RNA editing with endogenous ADAR has the potential to present an attractive option for the treatment of inherited retinal diseases (IRDs), a field where gene replacement therapy has been established as safe and efficacious, but where an unmet need still exists for genes that exceed the packaging capacity of an adeno associated virus (AAV) or are expressed in more than one retinal isoform. This review aims to give an overview of the recent developments in the field of RNA editing with endogenous ADAR and assess its applicability for the field of treatment of IRD

Combining climatic projections and dispersal ability: A method for estimating the responses of sandfly vector species to climate change

Abstract Background: In the Old World, sandfly species of the genus Phlebotomus are known vectors of Leishmania, Bartonella and several viruses. Recent sandfly catches and autochthonous cases of leishmaniasis hint on spreading tendencies of the vectors towards Central Europe. However, studies addressing potential future distribution of sandflies in the light of a changing European climate are missing

Debris discs around nearby Solar analogues

An unbiased search for debris discs around nearby Sun-like stars is reported. Thirteen G-dwarfs at 12-15 parsecs distance were searched at 850 \umum wavelength, and a disc is confirmed around HD 30495. The estimated dust mass is 0.008 M$_{\oplus}$ with a net limit \la 0.0025 M$_{\oplus}$ for the average disc of the other stars. The results suggest there is not a large missed population of substantial cold discs around Sun-like stars -- HD 30495 is a bright rather than unusually cool disc, and may belong to a few hundred Myr-old population of greater dust luminosity. The far-infared and millimetre survey data for Sun-like stars are well fitted by either steady state or stirred models, provided that typical comet belts are comparable in size to that in the Solar System.Comment: published in MNRA

A Planet at 5 AU Around 55 Cancri

We report precise Doppler shift measurements of 55 Cancri (G8V) obtained from 1989 to 2002 at Lick Observatory. The velocities reveal evidence for an outer planetary companion to 55 Cancri orbiting at 5.5 AU. The velocities also confirm a second, inner planet at 0.11 AU. The outer planet is the first extrasolar planet found that orbits near or beyond the orbit of Jupiter. It was drawn from a sample of ~50 stars observed with sufficient duration and quality to detect a giant planet at 5 AU, implying that such planets are not rare. The properties of this jupiter analog may be compared directly to those of the Jovian planets in our Solar System. Its eccentricity is modest, e=0.16, compared with e=0.05 for both Jupiter and Saturn. Its mass is at least 4.0 jupiter masses (M sin i). The two planets do not perturb each other significantly. Moreover, a third planet of sub-Jupiter mass could easily survive in between these two known planets. Indeed a third periodicity remains in the velocity measurements with P = 44.3 d and a semi-amplitude of 13 m/s. This periodicity is caused either by a third planet at a=0.24 AU or by inhomogeneities on the stellar surface that rotates with period 42 d. The planet interpretation is more likely, as the stellar surface is quiet, exhibiting log(R'_{HK}) = -5.0 and brightness variations less than 1 millimag, and any hypothetical surface inhomogeneity would have to persist in longitude for 14 yr. Even with all three planets, an additional planet of terrestrial--mass could orbit stably at ~1 AU. The star 55 Cancri is apparently a normal, middle-aged main sequence star with a mass of 0.95 solar masses, rich in heavy elements ([Fe/H] = +0.27). This high metallicity raises the issue of the relationship between its age, rotation, and chromosphere.Comment: 47 pages, 4 tables, 12 figures, uses AASTE

Is the Lecompte technique the last word on transposition of the great arteries repair for all patients? A magnetic resonance imaging study including a spiral technique two decades postoperatively.

ObjectivesTo compare the Lecompte technique and the spiral anastomosis (complete anatomic correction) two decades after arterial switch operation (ASO).MethodsNine patients after primary ASO with Lecompte and 6 selected patients after spiral anastomosis were evaluated 20.8 ± 2.1 years after ASO versus matched controls. Blood flow dynamics and flow profiles (e.g. vorticity, helicity) in the great arteries were quantified from time-resolved 3D magnetic resonance imaging (MRI) phase contrast flow measurements (4D flow MR) in addition to a comprehensive anatomical and functional cardiovascular MRI analysis.ResultsCompared with spiral reconstruction, patients with Lecompte showed more vortex formation, supranatural helical blood flow (relative helicity in aorta: 0.036 vs 0.089; P < 0.01), a reduced indexed cross-sectional area of the left pulmonary artery (155 vs 85 mm²/m²; P < 0.001) and more semilunar valve dysfunctions (n = 5 vs 1). There was no difference in elastic aortic wall properties, ventricular function, myocardial perfusion and myocardial fibrosis between the two groups. Cross-sectional area of the aortic sinus was larger in patients than in controls (669 vs 411 mm²/m²; P < 0.01). In the spiral group, the pulmonary root was rotated after ASO more towards the normal left position (P < 0.01).ConclusionsIn this study, selected patients with spiral anastomoses showed, two decades after ASO, better physiologically adapted blood flow dynamics, and attained a closer to normal anatomical position of their great arteries, as well as less valve dysfunction. Considering the limitations related to the small number of patients and the novel MRI imaging techniques, these data may provoke reconsidering the optimal surgical approaches to transposition of the great arteries repair

Probing Quantum Capacitance in a 3D Topological Insulator

We measure the quantum capacitance and probe thus directly the electronic density of states of the high mobility, Dirac type two-dimensional electron system, which forms on the surface of strained HgTe. Here we show that observed magnetocapacitance oscillations probe-in contrast to magnetotransport-primarily the top surface. Capacitance measurements constitute thus a powerful tool to probe only one topological surface and to reconstruct its Landau level spectrum for different positions of the Fermi energy

Debris disks as signposts of terrestrial planet formation. II Dependence of exoplanet architectures on giant planet and disk properties

We present models for the formation of terrestrial planets, and the collisional evolution of debris disks, in planetary systems that contain multiple unstable gas giants. We previously showed that the dynamics of the giant planets introduces a correlation between the presence of terrestrial planets and debris disks. Here we present new simulations that show that this connection is qualitatively robust to changes in: the mass distribution of the giant planets, the width and mass distribution of the outer planetesimal disk, and the presence of gas in the disk. We discuss how variations in these parameters affect the evolution. Systems with equal-mass giant planets undergo the most violent instabilities, and these destroy both terrestrial planets and the outer planetesimal disks that produce debris disks. In contrast, systems with low-mass giant planets efficiently produce both terrestrial planets and debris disks. A large fraction of systems with low-mass outermost giant planets have stable gaps between these planets that are frequently populated by planetesimals. Planetesimal belts between outer giant planets may affect debris disk SEDs. If Earth-mass seeds are present in outer planetesimal disks, the disks radially spread to colder temperatures. We argue that this may explain the very low frequency of > 1 Gyr-old solar-type stars with observed 24 micron excesses. Among the (limited) set of configurations explored, the best candidates for hosting terrestrial planets at ~1 AU are stars older than 0.1-1 Gyr with bright debris disks at 70 micron but with no currently-known giant planets. These systems combine evidence for rocky building blocks, with giant planet properties least likely to undergo destructive dynamical evolution. We predict an anti-correlation between debris disks and eccentric giant planets, and a positive correlation between debris disks and terrestrial planets.Comment: Astronomy and Astrophysics, in press. Movies from simulations are at http://www.obs.u-bordeaux1.fr/e3arths/raymond/movies_debris.htm